3-D composite scaffolds obtained by a supercritical fluids assisted process
نویسندگان
چکیده
One of the most important goals of tissue engineering is the design and the generation of a biocompatible porous 3-D structure, with high porosity, high interconnectivity and homogenous morphology. Nevertheless, the implantation of engineered biomaterials might cause local inflammation because of the host’s immune response. To overcome this limitation, in this study, 3-D polymeric composite scaffolds loaded with an active compound have been generated by supercritical freeze extraction process (SFEP). This is an innovative process that combines the advantages of the Thermally Induced Phase Separation (TIPS) process and of the supercritical carbon dioxide (SC-CO2) drying. Poly-l-lactid acid (PLLA)/ibuprofen composite scaffolds characterized by a 3-D geometry, micrometric cellular structures and wrinkled pore walls have been obtained; moreover, the homogeneous drug distribution inside the polymeric matrix and controlled release of the active compound have
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